Cette revue de vulgarisation en pdf c’est ici

Abstract

Cystic fibrosis is a disease caused by a mutation on the CFTR gene coding for achloride channel. The dominant mutation F508del eliminates the CFTR protein at the surfaceof epithelial cells, causing an accumulation of viscous mucus in the airways. In advanced stagesof the disease, respiratory failure is associated with cellular hypoxia. Our project aims notonly to describe the impact of hypoxia on ion channels and to highlight the underlying signalingpathways involved, but also to test the effectiveness of current CF treatments under the above-mentioned conditions.